Apo-Clozapine (clozapine) is contraindicated in patients with myeloproliferative disorders, a history of toxic or idiosyncratic agranulocytosis or severe granulocytopenia (with the exception of granulocytopenia/ agranulocytosis from previous chemotherapy).

(Clozapine should not be used simultaneously with other agents known to suppress bone marrow function.)

Apo-Clozapine is also contraindicated in patients with active liver disease associated with nausea, anorexia, or jaundice; progressive liver disease; hepatic failure.


 

Other contraindications include severe central nervous system depression or comatose states, severe renal or cardiac disease (eg. myocarditis), uncontrolled epilepsy, and previous hypersensitivity to clozapine or any other components of Apo-Clozapine.